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News for Healthier Living
CRISPR Screening Reveals H2AZ1 as a Key Driver of Mesenchymal Stem Cell Aging
 In a new discovery that may reshape anti-aging strategies, researchers have identified the histone variant H2A.Z variant histone 1 (H2AZ1) as a pivotal driver of cellular aging in human mesenchymal stem cells (hMSCs). By leveraging CRISPR-based genomic screening, the research team found that depletion of H2AZ1 can reverse cellular aging hallmarks and rejuvenate stem cell function. Conversely, its overexpression accelerates the aging process. The study unveils a novel epigenetic mechanism: H2AZ1 silences the secreted growth factor pleiotrophin (PTN), which is critical for tissue repair and hippocampal neurogenesis, by binding to its five enhancer regions (E1-E5), offering a new therapeutic target to delay aging and enhance regenerative medicine.
June 17, 2025
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