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News for Healthier Living
Lung Cancer Rewires Immune Cells in the Bone Marrow to Weaken Body's Defenses
Lung tumors don't just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature [10.1038/s41586-025-09493-y] that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy. Immunotherapies, which rally the body's defenses against cancer, have transformed care for many patients. But in solid tumors like non-small cell lung cancer (NSCLC), their success is often blunted by an influx of pro-tumoral macrophages--immune cells that suppress the body's anti-cancer response. Until now, scientists thought these macrophages turned rogue only after reaching the tumor.
September 10, 2025
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September 1 2025August 31 2025August 30 2025
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