News for Healthier Living

Cleveland Researchers Discover Nitric Oxide Rewires Gene Expression in the Brain, Offering New Insight into Alzheimer's Disease

* Alternative splicing is a process by which a single gene is edited to produce multiple different versions, thereby increasing the size of the functional genome. * In a new Molecular Cell study, researchers discovered that nitric oxide--a gas produced in the body--broadly regulates alternative splicing, dramatically altering gene function. * The team also found that nitric oxide levels are reduced in the brains of patients with Alzheimer's disease, and that this loss of regulation over gene splicing correlates with worse clinical outcomes. * Historically, researchers believed nitric oxide levels in Alzheimer's brains were too high and contributed to disease development. This study challenges that long-standing view.

May 21, 2026


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