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News for Healthier Living
Novel Study Explores How Different Types of Genetic Risk Impact the Manifestation of Alcohol Use Disorder
There are multiple types of genetic influence that impact the severity and presentation of alcohol use disorder (AUD). This is according to what may be the first study examining the joint effects of three types of genetic liability on alcohol outcomes. About half the risk for AUD is known to be genetically inherited. Some genetic influences manifest as struggles with self-regulation, such as childhood conduct problems and risk-taking ("externalizing" behaviors). Other genetic vulnerabilities show up as tendencies toward depression and negative affect ("internalizing" behaviors), while a third group of genetic influences is alcohol-specific (e.g., affecting how alcohol is metabolized). Large studies mapping relevant genetic variants are enabling polygenic scoring (PGS) that captures individuals' overall genetic susceptibility to AUD. The study in Alcohol: Clinical & Experimental Research explored how genetic factors underlying externalizing, internalizing, and alcohol-specific effects j
October 12, 2026
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Among Elementary- and Middle-School-Aged Children
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