trazodone

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Pronunciation: TRAZ oh done

Brand: Oleptro

Desyrel 150 mg

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rectangular, peach, imprinted with MJ 778, 50 50 50

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Trazodone 100 mg-BAR

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round, white, imprinted with barr, 555 490

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Trazodone 100 mg-MUT

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round, white, imprinted with MP 114

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Trazodone 100 mg-SID

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round, white, imprinted with SL 434

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Trazodone 100 mg-TEV

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round, white, imprinted with 93 638

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Trazodone 100 mg-WAT

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round, white, imprinted with 5599, DAN DAN

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Trazodone 150 mg-BAR

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oval, white, imprinted with barr 732, 50 50 50

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Trazodone 150 mg-MUT

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round, white, imprinted with 25 25 50 50, MP 168

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Trazodone 150 mg-SID

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trapezoid, white, imprinted with SL 441, 50 50 50

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Trazodone 150 mg-WAT

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round, white, imprinted with 2525 5050, MP168

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Trazodone 300 mg-BAR

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oval, white, imprinted with barr 733, 100 100 100

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Trazodone 50 mg-BAR

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round, white, imprinted with barr, 555 489

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Trazodone 50 mg-MUT

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round, white, imprinted with MP 118

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Trazodone 50 mg-SID

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round, white, imprinted with SL 433

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Trazodone 50 mg-TEV

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round, white, imprinted with 93 637

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Trazodone 50 mg-WAT

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What is the most important information I should know about trazodone?

You should not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection.

Do not use trazodone if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using trazodone. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Trazodone is not approved for use in children.

What is trazodone?

Trazodone is an antidepressant medicine. It affects chemicals in the brain that may be unbalanced in people with depression.

Trazodone is used to treat major depressive disorder.

Trazodone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking trazodone?

You should not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection.

To make sure trazodone is safe for you, tell your doctor if you have:

liver or kidney disease;
heart disease;
a bleeding or blood clotting disorder;
seizures or epilepsy;
narrow-angle glaucoma;
bipolar disorder (manic depression);
a history of Long QT syndrome;
a history of drug abuse or suicidal thoughts; or
if you have recently had a heart attack.

Taking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant while taking trazodone. Do not start or stop taking this medicine during pregnancy without your doctor's advice.

It is not known whether trazodone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Trazodone is not approved for use in children.

How should I take trazodone?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

The trazodone immediate-release tablet should be taken after a meal or a snack.

Take Oleptro on an empty stomach at bedtime or late in the evening.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. You may break an Oleptro tablet in half along the score line if needed.

It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using trazodone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using trazodone.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of trazodone can be fatal when it is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).

Overdose symptoms may include extreme drowsiness, vomiting, penis erection that is painful or prolonged, fast or pounding heartbeat, seizure (black-out or convulsions), or breathing that slows or stops.

What should I avoid while taking trazodone?

Do not drink alcohol. Trazodone can increase the effects of alcohol, which could be dangerous.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Trazodone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with trazodone may cause you to bruise or bleed easily.

What are the possible side effects of trazodone?

Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
chest pain or pressure, tight feeling in your neck or jaw, sweating, pain spreading to your arm or shoulder;
high levels of serotonin in the body --agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
low levels of sodium in the body --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or
severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

drowsiness, dizziness;
vision changes;
constipation; or
dry mouth, altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect trazodone?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking trazodone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with trazodone. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with trazodone, especially:

any other antidepressant;
anagrelide;
droperidol;
methadone;
ondansetron;
an antibiotic --azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
cancer medicine --arsenic trioxide, vandetanib;
anti-malaria medication --chloroquine, halofantrine;
heart rhythm medicine --amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or
medicine to treat a psychiatric disorder --chlorpromazine, haloperidol, pimozide, thioridazine.

This list is not complete and many other drugs can interact with trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about trazodone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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