chlorpheniramine, hydrocodone, and pseudoephedrine

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Pronunciation: KLOR fe NEER a meen, HYE droe KOE done, SOO doe ee FED rin

Brand: Hydron PCS, Hyphed, P-V-Tussin Syrup, Zutripro

What is the most important information I should know about chlorpheniramine, hydrocodone, and pseudoephedrine?

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

You should not use this medicine if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

What is chlorpheniramine, hydrocodone, and pseudoephedrine?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is a narcotic cough medicine.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Chlorpheniramine, hydrocodone, and pseudoephedrine is a combination medicine used to treat runny or stuffy nose, sinus congestion, and cough caused by the common cold or flu.

Chlorpheniramine, hydrocodone, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking chlorpheniramine, hydrocodone, and pseudoephedrine?

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use chlorpheniramine, hydrocodone, and pseudoephedrine if you are allergic to it, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

To make sure this medicine is safe for you, tell your doctor if you have:

  • blockage in your digestive tract (stomach or intestines);
  • diarrhea, inflammatory bowel disease;
  • a colostomy or ileostomy;
  • liver or kidney disease;
  • heart disease;
  • glaucoma;
  • bladder obstruction or other urination problems;
  • a head injury or brain tumor;
  • asthma, COPD, sleep apnea, or other breathing disorder;
  • a thyroid disorder;
  • pheochromocytoma (tumor of the adrenal gland);
  • low blood pressure; or
  • if you are dehydrated.

It is not known whether this medicine will harm an unborn baby. If you use hydrocodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

Chlorpheniramine, hydrocodone, and pseudoephedrine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How should I take chlorpheniramine, hydrocodone, and pseudoephedrine?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Hydrocodone may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

You may take this medication with or without food.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of hydrocodone can be fatal.

Overdose symptoms may include extreme drowsiness, pinpoint pupils, confusion, cold and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops.

What should I avoid while taking chlorpheniramine, hydrocodone, and pseudoephedrine?

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with hydrocodone.

What are the possible side effects of chlorpheniramine, hydrocodone, and pseudoephedrine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • pounding heartbeats or fluttering in your chest;
  • a light-headed feeling, like you might pass out;
  • severe anxiety, confusion, fear;
  • painful or difficult urination;
  • little or no urinating; or
  • dangerously high blood pressure --severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats.

Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

Common side effects may include:

  • dizziness, drowsiness;
  • mood changes;
  • blurred vision; or
  • nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlorpheniramine, hydrocodone, and pseudoephedrine?

Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

  • other narcotic medications --opioid pain medicine or prescription cough medicine;
  • drugs that make you sleepy or slow your breathing --a sleeping pill, muscle relaxer, sedative, tranquilizer, or antipsychotic medicine; or
  • drugs that affect serotonin levels in your body --medicine for depression, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.

This list is not complete. Other drugs may interact with chlorpheniramine, hydrocodone, and pseudoephedrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about chlorpheniramine, hydrocodone, and pseudoephedrine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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