quetiapine

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Pronunciation: kwe TYE a peen

Brand: SEROquel, SEROquel XR

Quetiapine 100 mg-APO

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Quetiapine 200 mg-APO

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Quetiapine 25 mg-APO

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Quetiapine 300 mg-APO

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capsule, white, imprinted with APO, QUE 300

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Quetiapine 400 mg-APO

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capsule, yellow, imprinted with APO, QUE 400

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Quetiapine 50 mg-APO

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round, white, imprinted with APO, QUE 50

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Seroquel 100 mg

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round, yellow, imprinted with SEROQUEL 100

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Seroquel 200 mg

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round, white, imprinted with SEROQUEL 200

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Seroquel 25 mg

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round, peach, imprinted with SEROQUEL 25

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Seroquel 300 mg

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oblong, white, imprinted with SEROQUEL, 300

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Seroquel 400 mg

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oblong, yellow, imprinted with SEROQUEL, 400

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Seroquel 50 mg

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What is the most important information I should know about quetiapine?

Some young people have thoughts about suicide when first taking quetiapine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Quetiapine is not approved for use in psychotic conditions related to dementia. Quetiapine may increase the risk of death in older adults with dementia-related conditions.

What is quetiapine?

Quetiapine is an antipsychotic medicine. It works by changing the actions of chemicals in the brain.

Quetiapine is used to treat schizophrenia in adults and children who are at least 13 years old.

Quetiapine is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Quetiapine is also used together with antidepressant medications to treat major depressive disorder in adults.

Extended-release quetiapine (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old.

Quetiapine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking quetiapine?

You should not use quetiapine if you are allergic to it.

Quetiapine is not approved for use in psychotic conditions related to dementia. Quetiapine may increase the risk of death in older adults with dementia-related conditions.

To make sure quetiapine is safe for you, tell your doctor if you have:

  • liver or kidney disease;
  • heart disease, heart rhythm problems, a history of heart attack or stroke;
  • high or low blood pressure;
  • a history of low white blood cell (WBC) counts;
  • abnormal thyroid tests or prolactin levels;
  • seizures or epilepsy;
  • cataracts;
  • high cholesterol or triglycerides;
  • a personal or family history of diabetes; or
  • trouble swallowing.

Some young people have thoughts about suicide when first taking quetiapine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking quetiapine, do not stop taking it without your doctor's advice.

Quetiapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using quetiapine.

Do not give quetiapine to a child without a doctor's advice. Extended-release quetiapine (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old.

How should I take quetiapine?

Follow all directions on your prescription label. Never take quetiapine in larger amounts, or for longer than recommended by your doctor. High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements.

Take this medicine with a full glass of water. You may take quetiapine with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Quetiapine may cause you to have high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking quetiapine.

You should not stop using quetiapine suddenly. Stopping suddenly may make your condition worse.

Blood pressure may need to be checked often in a child or teenager taking quetiapine.

Quetiapine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking quetiapine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of quetiapine can be fatal.

What should I avoid while taking quetiapine?

Avoid drinking alcohol. Dangerous side effects could occur.

Quetiapine may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.

Avoid becoming overheated or dehydrated during exercise and in hot weather. You may be more prone to heat stroke.

What are the possible side effects of quetiapine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • mask-like appearance of the face, trouble swallowing, problems with speech;
  • a light-headed feeling, like you might pass out;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting;
  • high blood sugar --increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or
  • low blood cell counts --sudden weakness or ill feeling, fever, chills, cold or flu symptoms, cough, sore throat, red or swollen gums, painful mouth sores, skin sores, trouble breathing.

Common side effects may include:

  • trouble with movement;
  • dizziness, weakness;
  • increased appetite, weight gain;
  • sore throat;
  • dry mouth; or
  • nausea, vomiting, stomach pain, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect quetiapine?

Quetiapine can cause a serious heart problem if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with quetiapine.

Taking quetiapine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with quetiapine. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • antibiotic or antifungal medicine;
  • antiviral medicine to treat hepatitis or HIV/AIDS;
  • heart or blood pressure medicine;
  • medicine to treat mental illness;
  • St. John's wort;
  • seizure medicine; or
  • tuberculosis medicine.

This list is not complete and many other drugs can interact with quetiapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about quetiapine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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