brompheniramine, hydrocodone, and pseudoephedrine

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Pronunciation: brom fen EER a meen, hye droe KOE dohn, soo doe e FED rin

Brand: Bromplex HD, Endacof HC, Visvex

What is the most important information I should know about brompheniramine, hydrocodone, and pseudoephedrine?

You should not use this medicine if you have bladder obstruction or urination problems, uncontrolled high blood pressure, severe coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or uncontrolled asthma.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.

What is brompheniramine, hydrocodone, and pseudoephedrine?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is a narcotic cough medicine.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Brompheniramine, hydrocodone, and pseudoephedrine is a combination medicine used to treat sneezing, runny or stuffy nose, watery eyes, and cough caused by allergies or the common cold.

Brompheniramine, hydrocodone, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking brompheniramine, hydrocodone, and pseudoephedrine?

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use brompheniramine, hydrocodone, and pseudoephedrine if you are allergic to it, or if you have:

  • bladder obstruction or other urination problems;
  • uncontrolled high blood pressure;
  • severe coronary artery disease (hardened arteries);
  • narrow-angle glaucoma;
  • a stomach ulcer; or
  • uncontrolled asthma.

To make sure this medicine is safe for you, tell your doctor if you have:

  • blockage in your digestive tract (stomach or intestines);
  • heart disease;
  • glaucoma;
  • liver or kidney disease;
  • a head injury or brain tumor;
  • asthma, COPD, sleep apnea, or other breathing disorder;
  • a thyroid disorder;
  • diabetes; or
  • pheochromocytoma (tumor of the adrenal gland).

It is not known whether this medicine will harm an unborn baby. If you use hydrocodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

Brompheniramine, hydrocodone, and pseudoephedrine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medication to anyone under 18 years old without medical advice.

How should I take brompheniramine, hydrocodone, and pseudoephedrine?

Follow all directions on your prescription label. Hydrocodone can slow or stop your breathing. Never use this medicine in larger amounts, or for longer than prescribed. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Hydrocodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away hydrocodone is against the law.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

Store at room temperature away from moisture and heat. Do not freeze. Keep track of the amount of medicine used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A hydrocodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.

What should I avoid while taking brompheniramine, hydrocodone, and pseudoephedrine?

This medicine may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Drinking alcohol with this medicine can cause side effects.

What are the possible side effects of brompheniramine, hydrocodone, and pseudoephedrine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • pounding heartbeats or fluttering in your chest;
  • a light-headed feeling, like you might pass out;
  • severe anxiety, confusion, fear;
  • painful or difficult urination;
  • little or no urinating; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

Common side effects may include:

  • dizziness, drowsiness, mood changes;
  • feeling excited or irritable;
  • problems with thinking or memory;
  • flushing (warmth, redness, or tingly feeling);
  • blurred vision; or
  • nausea, dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect brompheniramine, hydrocodone, and pseudoephedrine?

Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking brompheniramine, hydrocodone, and pseudoephedrine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with brompheniramine, hydrocodone, and pseudoephedrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about brompheniramine, hydrocodone, and pseudoephedrine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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