chlophedianol, phenylephrine, and triprolidine

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Pronunciation: KLOE fe DYE a nol, FEN il EFF rin, and trye PROE li deen

Brand: Prohist CD

What is the most important information I should know about chlophedianol, phenylephrine, and triprolidine?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

What is chlophedianol, phenylephrine, and triprolidine?

Chlophedianol is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Triprolidine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

The combination of chlophedianol, phenylephrine, and triprolidine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the common cold, or the flu.

Chlophedianol, phenylephrine, and triprolidine will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlophedianol, phenylephrine, and triprolidine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking chlophedianol, phenylephrine, and triprolidine?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

To make sure you can safely use this medicine, tell your doctor if you have any of these other conditions:

  • a blockage in your digestive tract (stomach or intestines), a colostomy or ileostomy;
  • diabetes;
  • liver or kidney disease;
  • epilepsy or other seizure disorder;
  • cough with mucus, or cough caused by emphysema or chronic bronchitis;
  • enlarged prostate or urination problems;
  • low blood pressure;
  • pheochromocytoma (an adrenal gland tumor); or
  • if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

You should not use take chlophedianol, phenylephrine, and triprolidine during the third trimester of pregnancy. Do not use cough or cold medicine without telling your doctor if you are pregnant or plan to become pregnant while using the medicine.

Chlophedianol, phenylephrine, and triprolidine may pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use cough or cold medicine without telling your doctor if you are breast-feeding a baby.

How should I take chlophedianol, phenylephrine, and triprolidine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days.

Store at room temperature away from moisture and heat. Do not freeze.

What happens if I miss a dose?

Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking chlophedianol, phenylephrine, and triprolidine?

This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Ask a doctor or pharmacist before using any other cold, allergy, cough, or sleep medicine. Antihistamines, antitussives, and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Drinking alcohol can increase certain side effects of chlophedianol, phenylephrine, and triprolidine.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Chlophedianol, phenylephrine, and triprolidine can decrease sweating and you may be more prone to heat stroke.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

What are the possible side effects of chlophedianol, phenylephrine, and triprolidine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

  • fast or uneven heart rate;
  • chest tightness, wheezing;
  • severe dizziness or anxiety, feeling like you might pass out;
  • severe headache, mood changes, hallucinations;
  • tremor, seizure (convulsions);
  • easy bruising or bleeding, unusual weakness;
  • fever;
  • urinating less than usual or not at all;
  • feeling short of breath; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, uneven heartbeats, seizure).

Less serious side effects may include:

  • mild dizziness or drowsiness;
  • mild headache;
  • dry mouth, nose, or throat;
  • constipation, upset stomach, loss of appetite;
  • feeling nervous or restless;
  • blurred vision; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlophedianol, phenylephrine, and triprolidine?

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlophedianol or triprolidine.

Tell your doctor about all other medicines you use, especially:

  • atropine (Atreza, Sal-Tropine);
  • benztropine (Cogentin);
  • topiramate (Topamax);
  • zonisamide (Zonegran);
  • an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil, Pexeva), sertraline (Zoloft), venlafaxine (Effexor), and others;
  • anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), droperidol (Inapsine), methscopolamine (Pamine), or scopolamine (Transderm Scop);
  • bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;
  • bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
  • irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or
  • ulcer medicine such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

This list is not complete and other drugs may interact with chlophedianol, phenylephrine, and triprolidine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about chlophedianol, phenylephrine, and triprolidine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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