chlorpheniramine and dextromethorphan

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Pronunciation: klor feh NEER a meen and DEX troe meh THOR fan

Brand: Children's NyQuil Cold & Cough, Coricidin HBP Cough & Cold, Dimetapp Long Acting Cough Plus Cold, Robitussin Pediatric Cough & Cold Long-Acting, Triaminic Cough & Runny Nose, Tricodene Sugar Free

What is the most important information I should know about chlorpheniramine and dextromethorphan?

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

What is chlorpheniramine and dextromethorphan?

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Chlorpheniramine and dextromethorphan is a combination medicine used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and cough caused by allergies, the common cold, or the flu.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlorpheniramine and dextromethorphan may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking chlorpheniramine and dextromethorphan?

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

  • asthma or COPD, cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;
  • a blockage in your stomach or intestines;
  • glaucoma;
  • kidney disease;
  • liver disease;
  • diabetes;
  • heart disease or high blood pressure;
  • a thyroid disorder;
  • cough with mucus, or cough caused by emphysema or chronic bronchitis;
  • enlarged prostate or urination problems; or
  • if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

It is not known whether chlorpheniramine and dextromethorphan will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant.

This medication may pass into breast milk and may harm a nursing baby. Antihistamines may also slow breast milk production. Do not use this medicine without your doctor's advice if you are breast-feeding a baby.

Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).

How should I take chlorpheniramine and dextromethorphan?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

The chewable tablet must be chewed before you swallow it.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking chlorpheniramine and dextromethorphan?

Ask a doctor or pharmacist before using any other cold, allergy, or sleep medication. Chlorpheniramine and dextromethorphan are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain medicine. Check the label to see if a medicine contains an antihistamine or cough suppressant (antitussive).

This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Drinking alcohol can increase certain side effects of chlorpheniramine.

What are the possible side effects of chlorpheniramine and dextromethorphan?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • fast, slow, or uneven heart rate;
  • severe dizziness or anxiety, feeling like you might pass out;
  • mood changes, severe headache;
  • fever;
  • tremor, seizure (convulsions);
  • little or no urinating; or
  • easy bruising or bleeding, unusual weakness.

Common side effects may include:

  • mild dizziness, drowsiness;
  • dry mouth, nose, or throat;
  • constipation, diarrhea;
  • blurred vision; or
  • feeling nervous, restless, or irritable.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlorpheniramine and dextromethorphan?

Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking chlorpheniramine and dextromethorphan with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Where can I get more information?

Your pharmacist can provide more information about chlorpheniramine and dextromethorphan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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