haemophilus b conjugate (PRP-OMP) vaccine

Skip to the navigation

Pronunciation: hem OFF il us B KON ju gate

Brand: Liquid PedvaxHIB

What is the most important information I should know about this vaccine?

Your child should not receive this vaccine if he or she has ever had an allergic reaction to a haemophilus B or meningococcal vaccine.

What is haemophilus B conjugate (PRP-OMP) vaccine?

Haemophilus influenzae type B (Hib) is a bacteria that can cause serious illness, including breathing problems or meningitis. Hib infection usually affects children and can be fatal.

Haemophilus B conjugate (PMP-OMP) vaccine is used to help prevent this disease in children. This vaccine is given to children between the ages of 2 months and 6 years old.

The vaccine works by exposing your child to a small amount of the bacteria or a protein from the bacteria, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body, and will not protect against other types of influenza.

Haemophilus B conjugate vaccine is not for use in children younger than 6 weeks or older than 6 years.

Like any vaccine, haemophilus B conjugate vaccine may not provide protection from disease in every person.

What should I discuss with my healthcare provider before receiving this vaccine?

Your child should not receive this vaccine if he or she has ever had an allergic reaction to a haemophilus B or meningococcal vaccine.

If your child has any of these other conditions, this vaccine may need to be postponed or not given at all:

  • severe immune suppression caused by disease (such as cancer, HIV, or AIDS), or by receiving certain medicines such as steroids, chemotherapy or radiation;
  • a history of seizures;
  • an allergy to latex rubber; or
  • a bleeding or blood clotting disorder such as hemophilia or easy bruising.

Your child can still receive a vaccine if he or she has a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until the child gets better before receiving this vaccine.

This vaccine should not be given to anyone age 6 or older, and it is not known whether the vaccine is harmful during pregnancy or while breast-feeding.

How is this vaccine given?

This vaccine is injected into a muscle. Your child will receive this injection in a doctor's office or clinic setting.

This vaccine is given in a series of shots. The first shot is usually given when the child is 2 months old. The booster shots are then given at 4 months and 6 months of age, and again at 12 to 15 months of age.

For children who do not start this series of shots before 15 months of age, the vaccine is usually given as a one-time injection. Unless your doctor's tells you otherwise, you will not need a booster vaccine.

Your child's individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in.

Your doctor may recommend treating fever and pain with an aspirin free pain reliever such as acetaminophen (Tylenol) or ibuprofen (Motrin, Advil, and others) when the shot is given and for the next 24 hours. Follow the label directions or your doctor's instructions about how much of this medicine to give your child.

It is especially important to prevent fever from occurring in a child who has a seizure disorder such as epilepsy.

What happens if I miss a dose?

Contact your doctor if you will miss a booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.

Be sure your child receives all recommended doses of this vaccine. If your child does not receive the full series of vaccines, he or she may not be fully protected against the disease.

What happens if I overdose?

An overdose of this vaccine is not likely to occur.

What should I avoid before or after receiving this vaccine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of this vaccine?

Get emergency medical help if your child has signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects.

Becoming infected with haemophilus B is much more dangerous to your child's health than receiving this vaccine. Like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Call your doctor at once if your child has:

  • high fever (within a few hours or a few days after the vaccine);
  • seizure (blackout-out or convulsions); or
  • fussiness, irritability, crying for an hour or longer.

Common side effects may include:

  • diarrhea; or
  • pain, swelling, or redness where the shot was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What other drugs will affect this vaccine?

Other drugs may interact with haemophilus B conjugate vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell the doctor about all medications and treatments your child has recently received. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your doctor or pharmacist can provide more information about this vaccine. Additional information is available from your local health department or the Centers for Disease Control and Prevention.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 2.03. Revision date: 12/8/2015.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.