necitumumab
What is the most important information I should know about necitumumab?Necitumumab can cause your electrolytes to become unbalanced. This can lead to serious heart problems, including cardiac arrest. You will need frequent blood tests to check your electrolytes (calcium, potassium, and magnesium). What is necitumumab?Necitumumab is a monoclonal antibody that blocks a certain protein in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage. Necitumumab is used to treat a certain type of non-small cell lung cancer. Necitumumab is usually given in combination with other cancer medications. Necitumumab may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before receiving necitumumab?You should not be treated with necitumumab if you are allergic to it. To make sure necitumumab is safe for you, tell your doctor if you have: - coronary artery disease (hardened arteries);
- high blood pressure;
- chronic obstructive pulmonary disease (COPD);
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
- a history of heart attack or stroke.
Using necitumumab during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose. It is not known whether necitumumab passes into breast milk or if it could harm a nursing baby. Do not breast-feed while you are being treated with necitumumab, and for at least 3 months after your last dose. How is necitumumab given?Necitumumab is injected into a vein through an IV. A healthcare provider will give you this injection. This medicine must be injected slowly, and the IV infusion can take at least 1 hour to complete. Necitumumab is given in a 21-day treatment cycle. You may need to use the medicine only on days 1 and 8 of each cycle. Your doctor will determine how long to treat you with necitumumab. You may be given medication to prevent certain side effects while you are receiving necitumumab. Necitumumab can cause your electrolytes to become unbalanced. This can lead to serious heart problems, including cardiac arrest. You will need frequent blood tests to check your electrolytes (calcium, potassium, and magnesium). Your doctor may recommend that you take mineral supplements to keep your electrolytes from getting too low. Follow your doctor's dosing instructions very carefully. Necitumumab can have long-lasting effects on your body. You may need frequent medical tests for at least 8 weeks after you stop using this medicine. What happens if I miss a dose?Call your doctor for instructions if you miss an appointment for your necitumumab injection. What happens if I overdose?Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include headache, nausea, or vomiting. What should I avoid while receiving necitumumab?Avoid exposure to sunlight or tanning beds. Necitumumab can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. What are the possible side effects of necitumumab?Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some side effects may occur during the injection. Tell your caregiver right away if you feel chilled or feverish, or if you have trouble breathing. Call your doctor at once if you have: - acne-like skin rash;
- thickened skin or a hard lump where the medicine was injected;
- slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
- chest pain or pressure, pain spreading to your jaw or shoulder;
- signs of a blood clot --sudden numbness or weakness, problems with vision or speech, sudden cough, wheezing, coughing up blood, pain or swelling in an arm or leg; or
- symptoms of an electrolyte imbalance --numbness or tingling, irregular heartbeats, muscle tightness, tremors, muscle weakness or limp feeling, leg cramps, increased thirst or urination, behavior changes, seizure (convulsions).
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include: - vomiting, diarrhea;
- skin rash; or
- low levels of magnesium in your blood.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect necitumumab?Other drugs may interact with necitumumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Where can I get more information?Your doctor or pharmacist can provide more information about necitumumab.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2017 Cerner Multum, Inc. Version: 1.01. Revision date: 1/5/2016.
Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.
Last modified on: 8 September 2017
|
|